Monday, 12.9.2011
7.00-8.00 Main Hall (Aula Duza)
Genzyme Satellite Symposium
Title: Ablation at the cutting edge; defining new treatment paradigms for the 21st Century
Chairman: Martin Schlumberger (Paris, France)
7:00-7:15 Introduction: what is the rationale for ablation in thyroid cancer management?
Martin Schlumberger (Paris, France)
7:15-7:30 The UK HiLo study: final efficacy results
Ujjal Mallick (Newcastle, UK)
7:30-7:45 The French ESTIMABL ablation study. What are the implications for practice?
Isabelle Borget (Paris, France )
7:45-8:00 Round table discussion and questions
8.00-10.00 Main Hall (Aula Duza)
Oral presentations 4: Thyroid Autoimmunity (OP23-OP30)
Chair: Jadwiga Furmaniak (Cardiff, UK); Wojciech Zgliczynski (Poland)
OP23 DIFFERENCES IN THE WAY STIMULATING AND BLOCKING MONOCLONAL AUTOANTIBODIES INTERACT WITH THE TSHR
Núñez Miguel R1, Sanders J1, Young S1, Sanders P1, Kabelis K1, Clark J1, Wilmot J1, Evans M1, Hu X1, Roberts E1, Furmaniak J1, Rees Smith B1
1FIRS Laboratories, RSR Ltd, Cardiff, United Kingdom
OP24 CAVEOLINE-1 EXPRESSION DIFFERS ACCORDING TO THE TYPE OF IMMUNE REACTION (TH1/TH2) INVOLVED IN THYROID AUTOIMMUNE DISORDERS
Marique L1, Van Regemorter V1, Craps J1, Senou M1, Gérard A-C1, Many M-C1
1UCL, MORF, Brussels, Belgium
OP25 NEWLY IDENTIFIED IMMUNOSUPPRESSIVE NATURAL KILLER (NK) CELLS SUPPRESS ANTIGEN-SPECIFIC CD8+ T CELLS IN THREE MOUSE MODELS FOR AUTOIMMUNITY
Ehlers M1, Papewalis C1, Thiel A1, Jacobs B2, Ullrich E2, Willenberg HS1, Schinner S1, Scherbaum WA1, Schott M1
1University Hospital Duesseldorf, Endocrine Unit, Duesseldorf, Germany, 2University of Erlangen-Nürnberg, Erlangen, Germany
OP26 INVOLVEMENT OF STRESS IN THE PATHOGENESIS OF AUTOIMMUNE THYROID DISEASE: A PROSPECTIVE STUDY
Effraimidis G1, Tijssen JGP2, Wiersinga WM1
1Academic Medical Centre, University of Amsterdam, Department of Endocrinology and Metabolism, Amsterdam, Netherlands, 2Academic Medical Centre, University of Amsterdam, Department of Cardiology, Amsterdam, Netherlands
OP27 ROLE OF THE PRO-PEPTIDE SEQUENCE IN THYROID PEROXIDASE FUNCTION AND MATURATION
Godlewska M1, Banga JP2, Sutton BJ3, Krasuska W1, Weetman AP4, Kemp EH4, Góra M5
1Medical Centre of Postgraduate Education, Department of Biochemistry and Molecular Biology, Warsaw, Poland, 2King's College London School of Medicine, Division of Diabetes and Nutrition Sciences, London, United Kingdom, 3King's College London School of Medicine, Randall Division of Cell & Molecular Biophysics, London, United Kingdom, 4University of Sheffield, Department of Human Metabolism, Sheffield, United Kingdom, 5Institute of Biochemistry and Biophysics PAS, Department of Genetics, Warsaw, Poland
OP28 ALCOHOL CONSUMPTION IS PROTECTIVE FOR DEVELOPMENT OF AUTOIMMUNE HYPOTHYROIDISM - A POPULATION-BASED STUDY
Carlé A1, Pedersen IB1, Knudsen N2, Perrild H2, Ovesen L3, Rasmussen LB4, Jørgensen T5, Laurberg P1, The Danish Investigation of Iodine Intake and Thyroid Diseases (DanThyr)
1Aalborg Hospital, Aarhus University Hospital, Department of Endocrinology & Medicine, Aalborg, Denmark, 2Bispebjerg Hospital, Endocrine Unit, Medical Clinic I, Copenhagen, Denmark, 3Slagelse Hospital, Department of Internal Medicine, Slagelse, Denmark, 4National Food Institute, Technical University of Denmark, Department of Nutrition, Copenhagen, Denmark, 5Copenhagen County, Research Centre for Disease Prevention and Health, Copenhagen, Denmark
OP29 THYROID AUTOIMMUNITY IN MALIGNANT AND BENIGN BREAST DISEASE BEFORE SURGERY
Belardi V1, Giustarini E1, Fiore E1, Muller I1, Sabatini S1, Pinchera A1, Giani C1
1Università di Pisa, Endocrinology, Pisa, Italy
OP30 THYROID AUTOIMMUNITY AND HASHIMOTO'S THYROIDITIS AFTER UNIVERSAL IODINE PROPHYLAXIS: THE 2010 PESCOPAGANO SURVEY
Provenzale MA1, Fiore E1, Frigeri M1, Puleo L1, Antonangeli L1, Rago T1, Grasso L1, Pinchera A1, Aghini-Lombardi F1, Vitti P1
1Department of Endocrinology, University of Pisa, Pisa, Italy
8.00‐10.00 Minor Hall
Oral presentations 5: Thyroid Hormone 1 (OP31-OP38)
Chair: Jacques Dumont (Brussels, Belgium); Marek Bolanowski (Wroclaw, Poland)
OP31 EFFECT OF LACKING GPB5 ON DEIODINASE EXPRESSION IN PERIPHERAL TISSUES THAT EXPRESS THE THYROTROPIN RECEPTOR
Boelen A1, van Zeijl CJ1, Kwakkel J1, van Beeren HC1, Surovtseva OV1, Wiersinga WM1, Fliers E1
1Academic Medical Center, Endocrinology and Metabolism, Amsterdam, Netherlands
OP32 ANALYSIS OF MOUSE MUTANTS DEFICIENT IN THE THYROID HORMONE TRANSPORTER OATP1C1
Mayerl S1, Visser TJ2, Darras VM3, Heuer H1
1Leibniz Institute for Age Research/Fritz Lipmann Institute, Jena, Germany, 2Erasmus Medical Center, Rotterdam, Netherlands, 3Katholieke Universiteit, Leuven, Belgium
OP33 CARDIAC INDUCTION OF THE THYROID-HORMONE DEGRADING ENZYME DEIODINASE TYPE III IN HUMAN ISCHEMIC HEART DISEASE
Muller A1, Pol C1, Janssen R1, Zuidwijk M1, Joseph S2, Cameron D2, dos Remedios C2, Visser T3, Paulus W1, Simonides W1
1VU University Medical Center, Amsterdam, Netherlands, 2The University of Sydney, Sydney, Australia, 3Erasmus University Medical Center, Rotterdam, Netherlands
OP34 DIFFERENTIAL EXPRESSION PATTERN OF THYROID HORMONE TRANSPORTERS IN THE MOUSE CNS
Hahn C1, Müller J1, Romanova D1, Mayerl S1, Friesema EC2, Visser TJ2, Heuer H1
1Leibniz Institute for Age Research/Fritz Lipmann Institute, Jena, Germany, 2Erasmus Medical Center, Rotterdam, Netherlands
OP35 LIVER THYROID HORMONE CONCENTRATIONS IN RATS ON AMIODARONE OR DRONEDARONE TREATMENT CORRELATE WITH LIVER DEIODINASE ACTIVITIES AND ARE INDEPENDENT OF LIVER THYROID HORMONE TRANSPORTERS
Beeren HCV1, Ackermans MT2, Wiersinga WM2, Fliers E2, Boelen A2
1Academic Medical Centre, University of Amsterdam, Endocrinology, Amsterdam, Netherlands, 2Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands
OP36 SELENIUM AND THYROID HORMONES IN POSTMENOPAUSAL HEALTHY WOMEN
Hoeg A1, Gogakos A2, Murphy E2, Mueller S1, Reid D3, Gluer CC4, Felsenberg D5, Roux C6, Eastell R7, Köhrle J1, Schomburg L1, Williams G2
1Charité Universitätsmedizin Berlin, Institute for Experimental Endocrinology, Berlin, Germany, 2Imperial College London, Department of Medicine and MRC Clinical Sciences Centre, London, United Kingdom, 3University of Aberdeen, School of Medicine and Dentistry, Aberdeen, United Kingdom, 4Universitätsklinikum Schleswig-Holstein, Kiel, Germany, 5Free University of Berlin, Berlin, Germany, 6Paris Descartes University, Paris, France, 7University of Sheffield, Sheffield, United Kingdom
OP37 REGULATION OF BRAIN TH SIGNALLING DURING THE PERINATAL PERIOD IN EUTHYROID AND HYPOTHYROID PUPS
Morvan-Dubois G1, Ghaddab R1, Seugnet I1, Veillard T1, Perret-Jeanneret M1, Clerget-Froidevaux M-S1, Demeneix B1
1UMR7221 CNRS/MNHN, Paris cedex, France
OP38 EFFECTS OF AMIODARONE (AMIO) ON THYROID HORMONE (TH) TRANSPORT AND METABOLISM
van Heerebeek RE1, Mandu N1, Friesema EC1, Chong L-F1, Visser TJ1
1Erasmus MC, Internal Medicine, Thyroid Lab, Rotterdam, Netherlands
10.00-10.30
Coffee Break
10.30-12.00 Minor Hall
Symposium 3 Basic: Profiling the thyroid
Chair: Mariastella Zannini (Naples, Italy); Andrzej Lewinski (Lodz, Poland)
Finding thyroid cancer markers by omics
Dagmar Führer (Essen, Germany)
Profiling thyroid embryology
Roberto Di Lauro (Naples, Italy)
Genome-wide analysis of thyroid signaling
Pilar Santisteban (Madrid, Spain)
10.30-12.00 Main Hall (Aula Duza)
Symposium 4 Clinical: Where are the limits of overdiagnosis and overtreatment of thyroid disease?
Chair: Peter Laurberg (Aalborg, Denmark); Barbara Jarzab (Gliwice, Poland)
Thyroid nodules: indications to and extent of surgery
Henning Dralle (Halle, Germany)
Thyroid autoimmunity
Stefano Mariotti (Cagliari, Italy)
Subclinical functional abnormalities in the elderly
Simon Pearce (Newcastle, UK)
12.00-13.00 Poster Exhibition Area
Lunch and Poster Discussions 2 (see separate PDF for further information)
Thyroid Cancer (clinical) 4: Posters PO116-PO125 / Chair: Chantal Daumerie (Brussels, Belgium)
Thyroid Cancer (clinical) 5: Posters PO126-PO135 / Chair: Valeriano Leite (Lisbon, Portugal)
Thyroid Cancer (clinical) 6: Posters PO136-PO145 / Chair: Bengt Hallengren (Malmö, Sweden)
Thyroid Cancer (basic/translational) 2: Posters PO146-PO154 / Chair: Rosa Marina Melillo (Naples, Italy)
Graves’ Hyperthyroidism 2: Posters PO155-PO165 / Chair: Colin Dayan (Cardiff, UK)
Thyroid Hormone & Metabolism 2: Posters PO166-PO172 / Chair: Jean-Louis Wemeau (Lille, France)
Goiter/Nodules 1: Posters PO173-PO185 / Chair: Roland Gärtner (Munich, Germany)
Imaging in Thyroidology: Posters PO186-PO201 / Chair: Murat Erdogan (Ankara, Turkey)
Trace elements and environment: Posters PO202-PO211 / Chair: Nils Knudsen (Smorum, Denmark)
13.00-14.00 Main Hall (Aula Duza)
IBSA Satellite Symposium
Levothyroxine malabsorption: experience with the softgel capsules
Chairmen: Aldo Pinchera (Pisa, Italy) and George J. Kahaly (Mainz, Germany)
13.00 Welcome and introduction
George J. Kahaly (Mainz, Germany)
13.05 The pharmacokinetics of levothyroxine softgel capsules
Murray P. Ducharme (Montreal, Canada)
13.15 Novel developments with softgel capsules
Salvatore Benvenga (Messina, Italy)
13.30 Individually tailored dose of thyroxine: a role for gastric acid secretion
Marco Centanni (Latina, Italy)
13.45 Round-table discussion
Moderation: Aldo Pinchera (Pisa, Italy)
14.00 End of session
13.00 ‐ 14.00 Minor Hall
TFI‐ETA Patient‐Forum
Thyroid Federation International and European Thyroid Association invite all patients to the annual TFI‐ETA Patient‐Forum.
13.00 Opening by Yvonne Andersson, Sweden (President of TFI)
13.05 "Thyroid cancer, diagnostic, treatment and perspectives".
The latest developments on patient level on thyroid cancer
Martin Schlumberger (Paris, France)
13:25 "Psychological aspects of work with Thyroid Cancer Patients"
The psychological effects of thyroid cancer on patients and how to deal with them
Anna Syska‐Bielak (Gliwice, Poland)
13:45 Questions by patients
13:55 Round up by Yvonne Andersson
During the lectures and the questions Polish doctors will be available for translations.
14.00-14.45 Main Hall (Aula Duza)
ETA Merck Serono Prize Lecture
Chair: Luigi Bartalena (Varese, Italy); Peter Laurberg (Aalborg, Denmark)
Wilmar Wiersinga (Amsterdam, The Netherlands)
Autoimmunity in Graves' ophthalmopathy: a translational approach
14.45-15.00
Coffee Break
15.00-15.45
Meet the Expert
MTE 5 (B) MTE Hall: Non-nuclear thyroid hormone actions
Lutz Schomburg (Berlin, Germany)
MTE 6 (C) Lecture Hall: Rare causes of altered thyroid function tests
Graham Williams (London, UK)
MTE 7 (C) Senate Hall: Thyroid hormones and obesity
Leonidas Duntas (Athens, Greece)
MTE 8 (C) Minor Hall: Guideline-oriented diagnosis and treatment of thyroid nodules
Ralf Paschke (Leipzig, Germany)
16.30
Departure for Excursion
Subclinical hypothyroidism through all ages
Chairperson: George J. Kahaly (Mainz, Germany)
18.30 Welcome Introduction
George J. Kahaly
18.45 Management of subclinical hypothyroidism during pregnancy and the postpartum
Kris Poppe, (Brussels, Belgium)
19.10 Increased morbidity and cardiovascular risk in subclinical hypothyroidism
Simon H. Pearce (Newcastle upon Tyne, UK)
19.35 Personalized rationale for thyroid hormone replacement
Antonio C. Bianco (Miami, USA)
Symposium participants are cordially invited to a cocktail reception immediately following the event.
